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THE CLINICAL UTILITY OF POSITION EMISSION TOMOGRAPHY FOR INITIAL DIAGNOSIS AND FOLLOW UP CHECK IN ORAL AND MAXILLOFACIAL CANCER PATIENTS

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±è¿ë°¢/Yong Kack Kim ¹ÚÇü±¹/ÇöÀçÈÆ/±èÀçȯ/Á¶º´È£/Hyung Kook Park/Jae Hoon Hyun/Jae Hwan Kim/Byung Ho Cho

Abstract

°á·Ð
¾çÀüÀÚ ¹æÃâ ´ÜÃþ ÃÔ¿µ(Positron Emission Tomography, PRT)Àº Á¾¾çÀÇ ´ë»çÀû Ư¼ºÀ»
ÀÌ¿ëÇØ ±â´ÉÀû ¿µ»ó(functional image)À» Á¦°øÇØ ÁÖ´Â »õ·Î¿î Áø´Ü¹ýÀ¸·Î ±¸°­¾Ç¾È¸é ¿µ¿ªÀÇ
¾ÏÁ¾ Áø´Ü¿¡ À־ Á¶±â Áø´Ü, º´±â °áÁ¤ ¹× Ä¡·á°èȹÀÇ ¼ö¸³¿¡ À־ À¯¿ëÇϸ®¶ó °í·ÁµÈ
´Ù.
º» ¿¬±¸¿¡¼­ 33¸íÀÇ È¯ÀÚ¸¦ ´ë»óÀ¸·Î ÃÊÁø ¥ð¡ÞÃßÀû°Ë»ç(follow up check)½Ã PETÀÇ À¯¿ë
¼ºÀ» Æò°¡ÇÑ °á°ú ÃÊÁø½Ã(14¸í) Á¤È®µµ(accuracy)´Â 78.6£¥, ¹Î°¨µµ(sensitivity) 88.9£¥, ƯÀÌ
µµ(,specificity) 60.0%·Î ³ª¿ÔÀ¸¸ç ÃßÀû °Ë»ç½Ã(19¸í) Á¤È®µµ´Â 84.2£¥, ¹Î°¨µµ 90.9£¥, ƯÀ̵µ
75.0£¥·Î ³ªÅ¸³µ´Ù.
PET´Â Àü½Å °Ë»ç¸¦ ½ÃÇàÇϱ⿡ ±¹¼ÒºÎÀ§ÀÇ º´±â ÆÇÁ¤»Ó ¾Æ´Ï¶ó ¿ø°ÝÀüÀÌ ¿©ºÎ¸¦ ÆǺ°ÇÒ
¼ö ÀÖ¾î, ±âÁ¸ÀÇ ¾Ï °Ë»ç¿¡¼­ Àü½Å °Ë»ç¸¦ À§ÇÑ ¸î °¡Áö ºÎ¼öÀûÀÎ °£´ÜÇÑ °Ë»ç¸¦ ´ëüÇÒ ¼ö
ÀÖÀ» °ÍÀ¸·Î »ç·áµÇ¾î ÃßÀû °Ë»ç½Ã À¯¿ëÇϸ®¶ó »ç·áµÈ´Ù.
ÇâÈÄ º»¿ø¿¡¼­´Â Á¶½É½º·± ȯÀÚ ¼±Åðú ´õºÒ¾î Ç¥ÁØÈ­µÈ °Ë»ç ±Ô¾à(protocol)À» ¼³Á¤ÇØ °è
¼ÓÀûÀ¸·Î PET¸¦ ¿¬±¸ÇÏ¿© ±âÁ¸ Áø´Ü¹ýµé°úÀÇ °´°üÀûÀÌ°í Åë°èÀûÀÎ ºñ±³¸¦ ÅëÇØ PETÀÇ À¯
¿ë¼ºÀ» ÀÔÁõÇÏ´Â °ÍÀÌ ÇÊ¿äÇϸ®¶ó »ý°¢µÇ¾îÁö¸ç, º¸´Ù ³ÐÀº PETÀÇ ÀÀ¿ë °¡´É¼º¿¡ ´ëÇÑ ¿¬
±¸°¡ ÇÊ¿äÇϸ®¶ó »ç·áµÈ´Ù.

BACKGROUND : Positron Emission Tomography(PET) with [18F]-fluorodeoxyglucose
(FDG) is a new imaging technique that has the advantage of imaging metabolic changes
linked to malignancy. PET-FDG can provide a functional image of the regional
biochemistry which may be more sensitive and accurate for detecting the presence of
tumor in early stage. Recently, the clinical use of PET scan has been studied in many
cancers but, there is a few clinical reports in oral and maxillofacial cancers.
We have evaluated the ability of PET-FDG for initial diagnosis and detection of early
subclinical recurrent malignancies in follow up check.
PATIENTS AND MATHODS : PET-FDG studies were performed in 33 patients from
October, 1997 to september, 1998. 14 patients underwent PET-FDG evaluation for initial
diagnosis and 19 patients for follow up check.
RESULTS : Evaluated for initial diagnosis, PET-FDG was found to have an overall
accuracy of 79£¥, sensitivity of 90£¥, specificity of 60£¥, positive predictive rate of 80£¥
and negative predictive rate of 75£¥.
Evaluated for follow up check, PET-FDG demonstrated accuracy of 84£¥, sensitivity
of 91£¥, specificity of 75£¥, positive predictive rate of 83£¥ and negative predictive rate
of 86£¥.
CONCLUSION : These data indicate that PET-FDG scan appears to be effective in
initial diagnosis and detection of early recurrent oral and maxillofacial malignancies.
The informations gained with PET-FDG can be included for essential treatment
planning because of possibility of detection for early subclinical malignancies and distant
metastases.

Positron Emission Tomography(PET); Initial Diagnosis; Follow Up Check; Oral and Maxillofacial Cancer;

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